Chemistry 9701 · AS & A Level · Nitrogen compounds

Nitrogen compounds — practice question

Human hair and silk are both made of proteins. Proteins are usually described as having three main levels of structure: primary, secondary and tertiary.
(a)[2]

Outline the meanings of primary structure and tertiary structure in a protein.

(b(i))[2]

Illustrate, with a diagram, the way disulfide cross-links are formed.

(b(ii))[1]

What type of reaction is shown?

(b(iii))[4]

State three further interactions that stabilise protein tertiary structure.

(c(i))[1]

What type of bonding stabilises the $\beta$-pleated sheet in silk?

(c(ii))[3]

On the diagram below, add a second polypeptide strand and show how the bonds that stabilise this $\beta$-pleated sheet would form.

(d)[1]

Suggest why the $\beta$-pleated sheet in $\beta$-keratin is much less flexible than the $\beta$-pleated sheet in silk.

(iii)[4]

State three further interactions that stabilise protein tertiary structure.

Worked solution & mark scheme

This 18-mark question has a full step-by-step worked solution and mark scheme. One marking point: Primary structure is the amino acid sequence

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