Biology 0610 · IGCSE · Monohybrid inheritance

Monohybrid inheritance — practice question

Huntington’s disease is a hereditary disorder caused by a change in one gene. The allele for Huntington’s disease is dominant and is shown by the letter H. The allele for no Huntington’s disease is recessive and is shown by the letter h. Fig. 3.1 is a pedigree chart showing the inheritance of Huntington’s disease in one family.
(a(i))[1]

State the number of males with Huntington’s disease in Fig. 3.1.

(a(ii))[2]

State the two possible genotypes for person 3 in Fig. 3.1.

(a(iii))[1]

State the evidence from Fig. 3.1 that suggests that the allele for Huntington’s disease is dominant.

(b)[3]

A person who is heterozygous for Huntington’s disease has a child with a person who is homozygous recessive. Complete the Punnett square in Fig. 3.2 by writing in the gametes and offspring for this cross and calculate the percentage chance that the child inherits Huntington’s disease.

(c(i))[2]

Define the term gene.

(c(ii))[1]

State where chromosomes are found in cells.

(c(iii))[1]

State the chromosomes involved in the inheritance of sex in humans.

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