Chemistry 9701 · AS & A Level · States of matter

States of matter — practice question

Certain metals are indispensable for biochemical processes.
(a)[2]

Fill in the table below by naming one metal for each case: haemoglobin in oxygen transport, transmission of nerve impulses, enzyme cofactor.

(b)[3]

Enzymes are a distinctive class of protein molecules that catalyse biochemical reactions. Explain briefly the mechanism by which an enzyme breaks down a substrate molecule.

(c(i))[1]

Disulfide bonds help stabilise some proteins such as the keratin in human hair. At which level of protein structure (primary, secondary, tertiary) are disulfide bonds formed?

(c(ii))[1]

Use a functional group in cysteine, $\text{H}_2\text{NCH(CH}_2\text{SH)CO}_2\text{H}$, to show how disulfide bonds are formed.

(c(iii))[1]

What kind of chemical reaction is this?

(d(i))[1]

The NMR spectrum of cysteine, $\text{H}_2\text{NCH(CH}_2\text{SH)CO}_2\text{H}$, gives five absorptions. After a solution of cysteine is shaken with a few drops of $\text{D}_2\text{O}$, the NMR spectrum shows only two absorptions, E and F. Identify the two types of protons responsible for the absorptions E and F.

(d(ii))[2]

State and explain the splitting patterns of the absorptions E and F.

Worked solution & mark scheme

This 11-mark question has a full step-by-step worked solution and mark scheme. One marking point: Fe for haemoglobin; Na/K for nerve impulses; Zn/Cu/Mg/Mn/Mo/Ni/Fe/Co for enzyme cofactors

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