Describe how cisplatin acts as an anticancer drug.
Suggest the geometry around the platinum centre in the carboplatin complex.
Suggest why carboplatin does not exhibit cis-trans isomerism.
Satraplatin is a neutral complex that contains the ligands $\text{CH}_3\text{CO}_2^-$, $\text{C}_6\text{H}_{11}\text{NH}_2$, $\text{Cl}^-$ and $\text{NH}_3$. Deduce the oxidation state of platinum in satraplatin.
Draw the structure for $L$.
Suggest reagents and conditions for each step in this synthesis. step 1 step 2
Write the equation for step 2.
A student looks at a possible route to make $M$ directly from benzene by using $\text{COCl}_2$ with an $\text{AlCl}_3$ catalyst. Benzene first reacts with $\text{COCl}_2$ as shown. reaction 1: $\text{COCl}_2 + \text{AlCl}_3 \rightarrow \text{AlCl}_4^- + \text{Cl}^-\text{C}\equiv\text{O}^+$ reaction 2: $\text{C}_6\text{H}_6 + \text{Cl}^-\text{C}\equiv\text{O}^+ \rightarrow \text{C}_6\text{H}_5\text{COCl} + \text{H}^+$ In Reaction 2, $\text{Cl}^-\text{C}\equiv\text{O}^+$ replaces $\text{H}^+$ on benzene by electrophilic substitution. Suggest a mechanism for reaction 2.