Chemistry 9701 · AS & A Level · Carboxylic acids and derivatives

Carboxylic acids and derivatives — practice question

Most common drugs are swallowed by mouth, whereas some medicines, including those made from protein molecules, are given by injection so that the digestive system does not break them down.
(a(i))

Identify a functional group in drug molecules that could be broken down by acid in the stomach.

(a(ii))

State the type of reaction that would bring about such a breakdown.

(a(iii))

Which one of the following compounds would be unsuitable for oral administration?

(a(iv))[5]

On the structure of your chosen compound in (iii), circle every functional group that could be broken down by acid.

(b(i))

State and explain at which location, P, Q or R, a hydrophobic drug could be carried.

(b(ii))[2]

By considering the functional groups in A, B and C, explain why these drugs can be carried at position R in the liposome.

(c(i))

Suggest a size for the nano-cages in metres.

(c(ii))[2]

Suggest why infra-red, instead of higher frequency radiation, is used.

Worked solution & mark scheme

This 9-mark question has a full step-by-step worked solution and mark scheme. One marking point: Peptide group or amide or ester

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