Describe how the 3 polypeptides are arranged in each collagen molecule.
Using Fig. 2.1, explain the arrangement of collagen molecules in a collagen fibril and how they are held together.
Suggest two properties of collagen that help cartilage function in the trachea in the gas exchange system of mammals.
State the role of elastic fibres in the alveoli in the lungs.
Complete Table 2.1 to show the amino acids encoded by the DNA nucleotide sequence in Table 2.1.
The amino acid sequence you have determined is representative of the entire collagen polypeptide. Explain how this amino acid sequence makes the polypeptide suitable for being part of a collagen molecule.
Two mutations, P and Q, may affect the primary structure of the polypeptide. Mutation P is a deletion of the first nucleotide pair in the DNA nucleotide sequence shown in Table 2.1. Mutation Q is a substitution of G with T as the first base in the DNA nucleotide sequence shown in Table 2.1. State the effects of mutations P and Q on the primary structure of the polypeptide. mutation P mutation Q