(a)[2]
Most enzymes are specific to one reaction. Using Fig. 3.1 as a reference, explain how an enzyme’s structure gives it specificity.
(b)[3]
The researchers concluded that GNF-5 acts as an inhibitor of the enzyme component of TKR and that it is a competitive inhibitor. Use Fig. 3.2 to give evidence for these conclusions.
(c)
A mutation in the gene coding for TKR changes the enzyme component of TKR. This altered version of TKR is called T315L. The effect of GNF-5 on the activity of T315L was also examined. The outcomes of this investigation are shown in Fig. 3.3.
(c(i))[1]
Use Fig. 3.2 and Fig. 3.3 to state how the activity of T315L differs from TKR when no GNF-5 was present.
(c(ii))[2]
State how the effect of GNF-5 on T315L is different from the effect of GNF-5 on TKR.