Biology 9700 · AS & A Level · Passage of information from parents to offspring

Passage of information from parents to offspring — practice question

During meiosis, homologous chromosomes can sometimes fail to separate at anaphase. This is called non-disjunction. Turner’s syndrome is the most common chromosome mutation in human females. It may arise because of non-disjunction in meiosis during gametogenesis. As a result, some gametes lack an X chromosome. In other cases of Turner’s syndrome, one chromosome from the X pair is not missing, but it is damaged instead. The damaged X chromosome may have broken and then rejoined, so that part of its structure has been lost. Fig. 7.1 shows a normal X chromosome together with two ‘damaged’ X chromosomes, $X_1$ and $X_2$. For $X_1$, part of the ‘p’ arm of the chromosome is absent. This deletion causes the female to have reduced height and abnormalities such as narrowing of the aorta. For $X_2$, part of the ‘q’ arm of the chromosome is absent. This deletion causes little or no development of the ovaries.
(a)[1]

Name the structure K.

(b)[2]

Explain why $X_1$ and $X_2$ give rise to different phenotypes.

(c)[4]

Mothers with the $X_1$ form of Turner’s syndrome can pass the chromosome mutation to their daughters, but not to their sons. Complete the genetic diagram below to show how the chromosome mutation $X_1$ can be passed on to daughters from a mother with Turner’s syndrome.

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