Biology 9700 · AS & A Level · Infectious diseases

Infectious diseases — practice question

Malaria is an infectious disease caused by the protoctist Plasmodium. During its life cycle, Plasmodium infects human red blood cells. Researchers can compare haemoglobin from the red blood cells of a healthy person with haemoglobin from a person with malaria.
(a)[1]

Worldwide, most malaria deaths are due to $P. vivax$ and $P. falciparum$. Name one other Plasmodium species that causes malaria.

(b(i))[2]

In the experiment used to obtain the results shown in Fig. 5.1, the temperature and pH were standardised. Explain what the researchers would take into account when choosing the temperature and pH for the experiment.

(b(ii))[3]

Using a different, quicker method, researchers compared the haemoglobin in the red blood cells of a healthy person with the haemoglobin of a person with malaria infected by $P. vivax$. From the data, the researchers concluded that the oxygen dissociation curve for a person with malaria would shift to the right. With reference to Fig. 5.1, explain how a rightward shift of the oxygen dissociation curve would influence oxygen loading in the lungs and unloading in respiring tissues in a person with malaria.

(i)[2]

In the experiment used to obtain the results shown in Fig. 5.1, the temperature and pH were standardised. Explain what the researchers would take into account when choosing the temperature and pH for the experiment.

(ii)[3]

Using a different, quicker method, researchers compared the haemoglobin in the red blood cells of a healthy person with the haemoglobin of a person with malaria infected by $P.\ vivax$. The results led them to conclude that the oxygen dissociation curve of a person with malaria would shift to the right. With reference to Fig. 5.1, explain how a rightward shift of the oxygen dissociation curve would influence oxygen loading in the lungs and unloading in respiring tissues in a person with malaria.

(c)[4]

A red blood cell infected with $Plasmodium$ is unable to perform its function as effectively as a normal red blood cell. Describe how the size and structure of a red blood cell are related to its function, apart from the fact that it contains a very large number of haemoglobin molecules.

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This 15-mark question has a full step-by-step worked solution and mark scheme. One marking point: Correct answer: ovale or malariae (correct spelling needed)

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