Biology 9700 · AS & A Level · Homeostasis in mammals

Homeostasis in mammals — practice question

Fig. 1.1 shows how antidiuretic hormone (ADH) affects the cells in the collecting duct. The cell-signalling pathway used by ADH is comparable to the one glucagon uses in liver cells.
(a)[3]

Name the structures A, B and C.

(b)[3]

When the water potential of the blood falls, the posterior pituitary gland secretes ADH. Suggest reasons why the water potential of the blood may decrease.

(c)[2]

Diabetes insipidus is a condition that affects kidney osmoregulation. One form of diabetes insipidus is due to a tumour in the pituitary gland, causing decreased secretion of ADH. Suggest the symptoms that would occur in a person with diabetes insipidus.

(d)[2]

Neurogenic diabetes insipidus (NDI) is another form of diabetes insipidus. In NDI, ADH molecules cannot bind to the receptor proteins found in the cell-surface membranes of the collecting duct cells. With reference to Fig. 1.1, explain the effect on the cell surface membrane labelled P if ADH cannot bind to the receptor proteins.

(e)[2]

NDI is caused by a recessive allele of the gene that codes for the receptor protein. The gene is on the X chromosome. Explain why a man with NDI could not have inherited the condition from his father.

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