Biology 9700 · AS & A Level · Homeostasis in mammals

Homeostasis in mammals — practice question

About 40% of adults who have cystic fibrosis (CF) go on to develop a type of diabetes called cystic fibrosis-related diabetes (CFRD). This is believed to occur because the accumulation of thick secretions in the pancreas destroys $\beta$ cells.
(a)[4]

Describe how destruction of $\beta$ cells leads to diabetes.

(b(i))[2]

Discuss whether there seems to be a positive correlation between chronic $P.\ aeruginosa$ infection and CFRD, referring to Table 4.1.

(b(ii))[2]

Calculate the percentage difference between the $\text{FEV}_1$ of males and females without CFRD and without $P.\ aeruginosa$ infection. Show your working.

(b(iii))[3]

Outline what conclusions can be drawn about the relationship between gender and the severity of lung damage in a person with CFRD and with $P.\ aeruginosa$ infection.

(c)[4]

In a person with CF, impaired lung function and the increased likelihood of chronic infections are caused by the secretion of thick mucus. Explain why thick mucus is secreted in the lungs of a person with CF.

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This 15-mark question has a full step-by-step worked solution and mark scheme. One marking point: $\beta$ cells sense blood glucose concentration

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